Dr Catherine Beech OBE, will present ‘New innovative technology, methods and systems ’at Pharmacology 2018 on Thursday 20 December 2018
Exonate is developing eye drops to revolutionise current standard-of-care in the treatment of eye diseases
Cambridge, UK – 30th November 2018: Exonate an early stage biotechnology company, today announces that its Chief Executive Officer Dr Catherine Beech OBE, will present at Pharmacology 2018 in London on Thursday 20th December 2018. She will present ‘New innovative technology, methods and systems’. The presentation will take place at 10.20 – 10.40.
Her presentation will focus on Exonate’s progress in developing a revolutionary, game changing eye drop for the treatment of retinal vascular diseases including wet AMD and diabetic macular oedema (DME). Exonate has developed small molecules that inhibit production of pro-angiogenic VEGF through selective inhibition of serine/threonine-protein kinase (SRPK1) - mediated VEGF splicing. Already, these inhibitors have demonstrated superior efficacy as topical agents in preclinical models of wAMD.
The British Pharmacological Society's flagship annual meeting attracts over 1,100 scientists each year from across the world. Each year the Society delivers a three-day event showcasing content led by the pharmacology community, through submitted symposia sessions and abstract presentations alongside invited speakers and commissioned content. Pharmacology runs from Tuesday 18th – Thursday 20th December 2018 and is based at the Queen Elizabeth II Conference Centre, London.
Dr Catherine Beech, Chief Executive Officer, commented:
“I am delighted to be presenting at Pharmacology 2018. This is an exciting time for Exonate as we work on a ground-breaking eye-drop treatment, and we look forward to providing further updates in due course.”
A copy of the presentation will be available on Exonate’s website www.exonate.com after the presentation. For further information on the meeting and to view the full programme please visit the Pharmacology website: https://www.bps.ac.uk/news-events/events/2018/december/pharmacology-2018
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Exonate is a privately held, early stage, biotech company spun out of the University of Nottingham that is focused on Vascular Endothelial Growth Factor (VEGF) in areas of unmet need, such as ophthalmology, pain, nephropathy and cancer. Exonate’s lead programme is focused on Diabetic macular oedema (DME). A consequence of diabetic retinopathy, DME is swelling in an area of the retina called the macula and wet Age-Related Macular Degeneration (wAMD), which is the leading cause of vision loss in people aged 60 and older. The Company is founded on scientific excellence with strong links to Professor David Bates and his lab at Nottingham University specialising in the biology and biochemical pathways of VEGF splice variants.
Exonate have developed small molecules that inhibit production of pro-angiogenic VEGF through selective inhibition of serine/threonine-protein kinase 1 (SRPK1)-mediated VEGF splicing. These inhibitors have already demonstrated superior efficacy as topical agents in preclinical models of wet AMD. Through a Wellcome Trust funded project, Exonate will complete an optimisation programme to nominate a pre-clinical candidate drug with optimal characteristics ahead of regulatory toxicology and safety pharmacology studies which will support an application to the regulatory authorities for clinical evaluation. Exonate expects to reach this milestone and enter the clinic in early 2020.
Exonate is led by an experienced, international management team that has previously worked together with cross-disciplinary experience in medicine and drug development, as well as successful fundraising for early stage companies.
About Diabetic macular oedema (DME)*:
DME is the build-up of fluid (edema) in a region of the retina called the macula. The macula is important for the sharp, straight-ahead vision that is used for reading, recognising faces, and driving. DME is the most common cause of vision loss among people with diabetic retinopathy. About half of all people with diabetic retinopathy will develop DME and although it is more likely to occur as diabetic retinopathy worsens, DME can happen at any stage of the disease.
About wet Age-Related Macular Degeneration (wAMD):
Today, wAMD is a leading cause of vision loss in people aged 60 years or older and affects more than 30 million patients worldwide, over 200,000 of those in the UK alone. If untreated patients are likely to lose sight in the affected eye within 24 months of disease onset.
The current standard-of-care treatment options for DME and wAMD are:
· anti-VEGF antibody drugs – to prevent the growth of new blood vessels in the eye. Unlike small molecule drugs or eye drops, these treatments must be injected into the eye once every 1-2 months. Resistance can develop to these drugs causing the disease to progress anew.
· laser surgery – to destroy abnormal blood vessels in the eye. This type of surgery is only suitable if blood vessel damage is not too extensive and if the abnormal blood vessels aren't close to the fovea, as performing surgery close to this part of the eye can cause permanent vision loss.
· With DME, Corticosteroids either injected or implanted into the eye, may be used alone or in combination with other drugs or laser surgery to treat DME